DIAGNOSIS AND TREATMENT OF EXOTIC DISHES

File: 121096_sep96_decls39_0017.txt
Page: 0017
Total Pages: 24

Subject: DIAGNOSIS AND TREATMENT OF EXOTIC DISHES                        

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES                                                      

Document Number:          1

Folder Seq  #:        180









                                     CLOSTRID@



                   A. CLMCAL SYNDROME
                   ClostridiuM perfiineens is a common anaerobic bacterium associ                 @th
            three distinct disease syndromes: (a) gas gangrene or clostridial myone
            (b) enteritis necroticans (pig-bel), (c) clostridial food poisoning. Each             e
            syndromes has very specific requirements for delivering inomk of
            12erfrinLyens to specific sites to induce disease, and it is difficult to envi:
            general scenario in which the spores or vegetative organisms could be i                a
            biowarfare agent. There are, however, at least 12 protein toxins elaboi
            and one or more of these could be produced, concentrated, and used as
            weapon. Waterbome disease is conceivable, but unlikely. The best av
            speculation (based on virtually no exploratory data with which to sharp4
            conclusions) is that the alpha toxin would be lethal by aerosol. This is
            characterized, highly toxic phospholipase C. Other toxins from the org
            might be co-weaponized and enhance effectiveness. For example, the c
            toxin is neurotoxic in laboratory animals.
                   Clinical Fean=:
                   The clinical picture of aerosoued C, perfrinszens alpha toxin woiu
            expected to be that of a serious acute pulmonary insult. Absorbed alplu-
            could produce vascular leak, hemolysis, thrombocytopenia, liver damage
            Other toxins admixed could modify the event.
                   B. DUGNOSIS

                   1. Routine Laborittory Findi=
                   Clinical laboratory findings might include anemia (due to intravas(
            hemolysis), thrombocytopenia, elevated serum transaminases, and hypox


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Document 24 f:/Week-36/BX003203/DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES/diagnosis and treatment of exotic dishes:12069615360440
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES
Folder Seq # = 180
Subject = DIAGNOSIS AND TREATMENT OF EXOTIC DISHES
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 06-DEC-1996