DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS

File: 123096_sep96_decls1_0048.txt
Page: 0048
Total Pages: 109

Subject: DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS       

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS                                       

Document Number:          1

Folder Seq  #:         21




                                                      UNCLASSIFIED
                                                          @C-. KR E!f

                       The organism itself is sensitive to penicillin, and, consequently, this is the cuffent


                drug of choice. Recent data indicate that clindamycin or rifampin may suppress toxin


                production, and provide superior results in animal models.


                       D.      PROPEIYLAXIS


                       There is no available prophylaxis for C, gcrfringens intoxication. Toxoids are being


                used to prevent enteritis necroticans in humans, and vete@ toxoids are in wide use.





                                                          PLAGUE


                       A: C@CAL SYNDROMEE


                       Plague is a zoonotic disease caused by Yersinia @, a gram negative, non spore-


                fomiing, bacillus. Under natural conditions, humans become infected through sldn


                inoculation (flea bite or direct animal contact), and only mdy @ aerosol. A biological

                warfare attack with plague bacilli could be delivered via contaminated vectors (fleas) or,

                more likely, via aerosol. The clinical picture seen would depend upon the route of delivery.

                       Clinical Features: The incubation period ranges from 2 to 10 days. Threoe primary

                syndromes are described: bubonic, primary septi@c, and pneumonic. In bubonic plague,

                onset is acute and often fulminant, with high fever, systemic signs and symptoms, and and

                exquisitely tender lymph node or nodes. 'rbe hallmark of bubonic plague, the bubo,


                                                             23               C-L@'3,31FIED 3@';
                                                    UNCLASSIFIED             E-
                                                                               @:CLA@iFy           DF?
                             sFepv7

Document 109 f:/Week-36/BX003203/DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS/detection of medical defense against biological :1217960927452
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS
Folder Seq # = 21
Subject = DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 17-DEC-1996