DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS

File: 123096_sep96_decls1_0050.txt
Page: 0050
Total Pages: 109

Subject: DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS       

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS                                       

Document Number:          1

Folder Seq  #:         21




                                                 UNCLASSIFIED



                      Bubonic plague should be suspected in large numbers of individuals with similar


               findings of fever, mal-dse, and tender lymphadenopathy. An epidemic of pnuemonic plague


               in its early stages could be confused with U=mia, anU=, or SEB; continued deterioration


               without stab@tion effectively rules out SEB, while gram stain of the sputum, culmm, and


               presence of the plague Fl antigen is blood specimens provide more specific evidence of


               plague.


                      3, Spmific Laboratory Diagnosis


                      Yersinia @ can be readily cultured from blood, sputum, and bubo aspirates.


               Presumptive diagnosis can be made by gram stain and (if available) immunofluorescent


               s@g. Most naturauy-=urring strains of Y, @ produce an 'Fl' antigen in-vivo,

               which can be detected in serum samples by immunoassays available in field diagnostic


               laboratories.


                      C. THERAPY


                      Untreated bubonic plague has a case-fatality rate commonly reported as around 50%;

               untreated primary septicemica and pnuemonic plague are invariably fatal. Streptomycin,

               tetracyclines, and chloramphenical are highly effective if begun early (within 8-24 hours in

               pneumonic plague). Intravenous doxycyline (200 mg initially, followed by 100 mg q 12

               hours), intramuscular streptomycin (I gm q 12 hours), or intravenous chloramphenicol (I gm


                                                  UNCLAGSIFIED            ILASSIFIED 13y: @,IUL71@-LE SOLJRCES
                                                                         ')ECLASoli:y C)N: C)AT;R

Document 109 f:/Week-36/BX003203/DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS/detection of medical defense against biological :1217960927452
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS
Folder Seq # = 21
Subject = DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 17-DEC-1996