DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS

File: 123096_sep96_decls1_0052.txt
Page: 0052
Total Pages: 109

Subject: DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS       

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS                                       

Document Number:          1

Folder Seq  #:         21





                                                  UNCLASSIFIED


                animals, or bites of infected deerflies, mosquitoes, or ticks. Rarely, ingestion of


                contaminated @s or water or inhalation of con         ted dusts may produce clinical


                disease. A biological warfare attack with L tularensis delivered by aerosol would primarily


                cause pneumonic and typhoidal tularemia, syndromes evwted to have case-fatality rates


                much higher dw the 5-10% seen when disease is acquired naturally.


                       Clinical Features


                       A variety of clinical forms of tuhiremia are seen, depending upon the mute of


                inoculation and vinilence of the strain. Since the infectious dose is low (1-10 organisms by


                aerosol or intradermal routes), ulceroglandular, typhoidal, pneumonic, or pharyngeal forms


                could be seen. Ulceroglandular tularemia genemny occurs about 3 days after exposure


                (range, 2-10 days), and manifests as a cutaneous ulcer with regional lymphadenopathy, fever,


                chills, headache, and malaise. With typhoidal disease, the systemic clinical manifestations


                are similar to those seen in the ulceroglandular fom, but the disease is not "contained* as a


                localized lesion. Both typhoidal and primary pneumonic disease may occur after inhalation of


                tularemia organisms; in the latter, clWcaUy and radiologicauy evident pneumonia dominates


                the clinical picture. Three to five days following inhalation, the abrupt onset of fever, chills,


                headache, myalgia, and prostration are seen, with a non-productive cough. Deposition of




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                                                  UNCLASSIFLED

Document 109 f:/Week-36/BX003203/DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS/detection of medical defense against biological :1217960927452
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIALS
Folder Seq # = 21
Subject = DETECTION OF MEDICAL DEFENSE AGAINST BIOLOGICAL
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 17-DEC-1996