MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL

File: 123096_sep96_decls28_0012.txt
Page: 0012
Total Pages: 40

Subject: MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL                     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL                                                     

Document Number:          1

Folder Seq  #:         47





                                          UNCLASSIFIED








            inferred from animal studies. Use requires pretesting for
            sensitivity to animal serum (and desensitization for those
            allergic), and disadvantages include rapid clearance by immune
            elimination, as well as theoretical risk of serum sickness.




                              STAPHYLO-COCCAL     OTOXIN B



                            Fi

              Staphylococcal enterotoxin B (SEB) is one of the several
            exotoxins produced by Staphylococcus a-@, causing food
            poisoning when ingested.

              A biological warfare attack with aerosol delivery of SEB to
            the respiratory tract produces a distinct syndrome causing
            significant morbidity and potential mortality.

              cliniral F     es. The disease begins 1-6,hours after
            exposure with the sudden onset of fever, chills, headache,
            myalgia, and non-productive cough. In more severe cases,
            dyspnea and retrosternal chest pain may also be present.
            Fever, which may reach 103-106 degrees F, has lasted 2-5 days,
            cough may persist 1-4 weeks. In many patients, nausea, which
            may be severe, vomiting, and diarrhea will also occur.
            Physical findings are often more unremarkable. Conjunctival
            injection may be present, and in the most severe cases, signs
            of pulmonary edema would be expected. The chest x-ray is
            generally normal, but in severe cases, there will be increased
            interstitial markings, atelectasis, and possible overt
            pulmonary edema. In moderately severe laboratory exposures,
            lost duty time has been greater than 2 weeks, but, based upon
            animal data, it is anticipated that severe exposures will
            result in fatalities.




                 Roiitine Laboratorv FindinaR. Laboratory findings are
r a neutrophilic leukocytosis and
              elevated erythrocyte sedimentation rate.

              0 Dif                   . . In foodborne SEB intoxication,
              fever and respiratory involvement are not seen, and
              gastrointestinal symptoms are prominent.


                                        UN&TASSIFIED

Document 40 f:/Week-36/BX003203/MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL/medical defense against biological material:12179609282229
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL
Folder Seq # = 47
Subject = MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 17-DEC-1996