RESPONSE TO THE BIOLOGICAL WARFARE BW THREAT 20 AUG 90

File: 120396_sep96_decls54_0012.txt
Page: 0012
Total Pages: 16

Subject: RESPONSE TO THE BIOLOGICAL WARFARE BW THREAT 20 AUG 90          

Unit: OTSG        

Parent Organization: HSC         

Box ID: BX003201

Folder Title: OPERATION DESERT SHIELD RESPONSE TO THE BIOLOGICAL WARFARE BW THREAT                            

Document Number:          1

Folder SEQ  #:         45







         product is present in very limited quantities at present, and is the preparation
         available from the Centers for Disease Control for treating suspected cases of
         foodbome botulism. Its efficacy is inferred from mixed case-report series, but
         is formally unproven outside animal studies. Use requires pre-testing for
         sensitivity to horse serum (and desensitization for those allergic), and
         disadvantages include rapid clearance (immune elimination, etc.) as well as the
         risk of serum sickness. We would recommend this product only for very
         limited, therapeutic, use.
               A "despeciated" equine heptavalent antitoxin (vs types A, B, C, D, E, F,
         and G) has been prepared by cleaving the Fc fragments from horse IgG
         molecules, leaving Fab'2. This technology has been applied successfully for the
         preparation of human anti-lymphocyte globulins. There is no experience in
         humans with this antitoxin, but there is no reason to believe its behavior would
 0       differ significantly from that of similarly prepared globulins. Once bottled and
         tested, we believe that this antitoxin might offer a possible option for post-
         exposure prophylaxis, but quantities and availability will be limited.















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Document 16 f:/Week-36/BX003201/OPERATION DESERT SHIELD RESPONSE TO THE BIOLOGICAL WARFARE BW THREAT/response to the biological warfare bw threat 20 :11229616342212
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003201
Unit = OTSG
Parent Organization = HSC
Folder Title = OPERATION DESERT SHIELD RESPONSE TO THE BIOLOGICAL WARFARE BW THREAT
Folder Seq # = 45
Subject = RESPONSE TO THE BIOLOGICAL WARFARE BW THREAT 20
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 22-NOV-1996