DIAGNOSIS AND TREATMENT OF EXOTIC DISHES

File: 121096_sep96_decls39_0011.txt
Page: 0011
Total Pages: 24

Subject: DIAGNOSIS AND TREATMENT OF EXOTIC DISHES                        

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES                                                      

Document Number:          1

Folder Seq  #:        180







          botulism, toxin may well be cleared from the blood by the time sympto
          noted. Nevertheless, serum should be obtained from representative cas
          such attempts. Survivors probably will not develop an antibody respon            to
          the small amount of toxin necessary to cause death. See Section M for            i
          of sample collection and processing.
                C. THERAPY

                Respiratory failure secondary to paralysis of respiratory muscles
          most serious complication and, generally, the cause of death. Reported           of
          botulism prior to 1950 had a mortality of 60%. With tracheostomy an@
          ventilatory assistance, fatalities should be <5%. Intensive and prolong
          nursing care may be required for recovery (which may take several wet
          even months).

                ANTITOXIN

                In isolated cases of foodbome botulism, circulating toxin is usual
          present, perhaps due to continued absorption through the gut wall. Equ
          antitoxin has been used in these circumstances, and is probably helpfid.
          aerosol exposure, it is unknown whether toxin circulates or antitoxin w(
          therapeutically useful after onset of symptoms. However, administration
          antitoxin is reasonable if disease has not progressed to a stable state.
                A human pentavalent antitoxin produced by plasmapheresis of tox
          vaccinees is available in y= limited quantities. It is an Investigational
          Drug (IND) and has never been tested for efficacy. Formal safety and
          pharmacokinetic studies are in progress. This product is useful only for
          specialized indications, and should not be considered as generally availa:
          There is no prospect for additional human antitoxin to be produced and

          available in the foreseeable future.

Document 24 f:/Week-36/BX003203/DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES/diagnosis and treatment of exotic dishes:12069615360440
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES
Folder Seq # = 180
Subject = DIAGNOSIS AND TREATMENT OF EXOTIC DISHES
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 06-DEC-1996