DIAGNOSIS AND TREATMENT OF EXOTIC DISHES

File: 121096_sep96_decls39_0012.txt
Page: 0012
Total Pages: 24

Subject: DIAGNOSIS AND TREATMENT OF EXOTIC DISHES                        

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES                                                      

Document Number:          1

Folder Seq  #:        180







                      despeciated" equine heptavalent antitoxin (vs types A, B, C,            F@
                        been prepared by cleaving the Fc fragments from horse lg(
                       leaving F(ab)2 fragments. Once bottled and tested, it is fell          iis
                            offer an option for therapy.
                  An equine trivalent (vs types A, B, and E) antitoxin is produced
            commercially in limited quantities. Its efficacy is inferred from mixed,
            report series, but is formally unproven outside animal studies. Use reA
            pre-testing for sensitivity to horse serum (and desensifimtion for those
            and disadvantages include rapid clearance by immune elimination, as,%             the
            risk of serum sickness. This product will not be generally available in

            field.

                  D. PROPHYLAXIS
                  A pentavalent toxoid of Clostridium botulinum types A, B, C, D
            is available under IND status. This product has been administered to s
            thousand volunteers and occupationally at-risk workers, and induces sei
            antitoxin levels which correspond to protective levels in experimental ai
            systems. The currently recommended schedule (0, 2, and 12 weeks, th
            year booster) induces solidly protective antitoxin levels in an acceptable
            percentage of vaccinees after 1 year. The little available data suggests
            limited and transient antitoxin levels are induced after 3 injections; there       0
            data currently available to assess immunogenicity after 1 or 2 doses, alt
            lower levels of antitoxin than those currently recommended for laborato
            workers may well offer protection in a field setting.
                  At present, this product is available in limited quantities, and mu$
            administered under protocol. Contraindications include sensitivity to all
r hypersensitivity to a previous dose.


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Document 24 f:/Week-36/BX003203/DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES/diagnosis and treatment of exotic dishes:12069615360440
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES
Folder Seq # = 180
Subject = DIAGNOSIS AND TREATMENT OF EXOTIC DISHES
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 06-DEC-1996